Acupuncture is over 2500 years old and practiced in most countries throughout the world. In the past three decades, there have been extensive studies on acupuncture and great efforts have been undertaken to conduct controlled clinical trials, including the use of “sham” acupuncture or “placebo” acupuncture controls. During the past decade, there has been a growing convergence between the most advanced research knowledge from physiology, biochemistry and pharmacology, and knowledge obtained by research in the field of acupuncture; that is to say, a convergence of modern international science with traditional Chinese medicine. 

Findings from basic medical research that acupuncture stimulation causes release of endorphins, serotonin, enkephalins, and γ-amino-butyric acid (GABA; a major inhibitory neurotransmitter of the brain), norepinephrine, and dopamine helped to explain the acupuncture effect on a biomedical and pharmacological basis that was acceptable to the Western medical establishment. Numerous articles are being published on the efficacy of acupuncture for many types of diseases. 

In the Americas and Europe there is significantly increased familiarity with acupuncture and thousands of patients have sought acupuncture treatment to relieve pain and stress-related syndromes, to enhance the immune system, to reduce insomnia, to improve athletic performance, to address neurological conditions, as well as for cardiac and poststroke therapy. From the viewpoint of modern medicine, the principle action of acupuncture is to regulate the function of the human body and to increase its resistance by enhancing the immune system and the antiphlogistic, analgesic, antispastic, antishock and antiparalytic abilities of the body.

 Acupuncture now occupies a unique place in modern medicine. Research on acupuncture has taken place in many universities and research institutions around the world, increasing our understanding of how the human body works. These articles only review a fraction of the research that has been conducted on acupuncture.


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Atalay, Nilgun Simsir, Fusun Sahin, Ali Atalay, and Nuray Akkaya. Comparison of efficacy of neural therapy and physical therapy in chronic low back pain. African Journal of Traditional, Complementary and Alternative Medicines 10, no. 3 (2013): 431-435.


Brand, H. Neural therapy in tinnitus. Wiener medizinische Wochenschrift (1946) 133, no. 21 (1983): 545-547.

Brobyn, T. L., M. K. Chung, and P. J. LaRiccia. Neural therapy: an overlooked game changer for patients suffering chronic pain. J. Pain Relief 4, no. 3 (2015): 1-4.


Caparso, Anthony V., Jon Parker, Andre B. Walker, and Yougandh Chitre. Systems and methods for delivering neural therapy correlated with patient status. U.S. Patent 8,355,797, issued January 15, 2013.


Dosch, Peter. Facts about neural therapy according to Huneke (regulating therapy): brief summary for patients. Haug, 1985.


Egli, Simon, Mirjam Pfister, Sabina M. Ludin, Katia Puente de la Vega, André Busato, and Lorenz Fischer. Long-term results of therapeutic local anesthesia (neural therapy) in 280 referred refractory chronic pain patients. BMC complementary and alternative medicine 15, no. 1 (2015): 200.

Epstein, Ervin. Triamcinolone-procaine in the treatment of zoster and post-zoster neuralgia. California medicine 115, no. 2 (1971): 6.

Fischer, L., and M. Pfister. Efficacy of Neural Therapy in Referred Patients with Chronic Therapy-Resistant Pain. Schweizerische Zeitschrift für Ganzheit Medizin 19, no. 1 (2007): 30.


Frank, Bryan L. Neural therapy. Physical Medicine and Rehabilitation Clinics 10, no. 3 (1999): 573-582.

Gibson, Robin Gordon, and Sheila Lilian Marjory Gibson. Neural therapy in the treatment of multiple sclerosis. The Journal of Alternative and Complementary Medicine 5, no. 6 (1999): 543-552.

Michael I. Gurevich, MD. Innovative Approach to Psychiatry: Treating Incurable Psychiatric Patients with Neural Therapy. Townsend Letter, October 2017.

Michael I. Gurevich, MD. Resolving Bulimia Nervosa Using An Innovative Neural Therapy Approach: Two Case Reports.


Hui, Fred, Eleanor Boyle, Eugene Vayda, and Richard H. Glazier. A randomized controlled trial of a multifaceted integrated complementary-alternative therapy for chronic herpes zoster-related pain. Alternative Medicine Review 17, no. 1 (2012).

Kidd, Robert F. Results of dental amalgam removal and mercury detoxification using DMPS and neural therapy. Alternative therapies in health and medicine 6, no. 4 (2000): 49.


Klinghardt, D. K. Neural therapy. Journal of Neurological and Orthopaedic Medicine and Surgery 14 (1993): 109-109.

Lecanu L, et al. Local anesthetic procaine protects rat pheochromocytoma PC12 cells against beta-amyloid-induced neurotoxicity. Pharmacology 2005;74(2):65–78.

Mermod, Joelle, Lorenz Fischer, Lukas Staub, and André Busato. Patient satisfaction of primary care for musculoskeletal diseases: a comparison between neural therapy and conventional medicine. BMC complementary and alternative medicine 8, no. 1 (2008): 33.


Walach, H. Methodologische Grundprinzipien der Neuraltherapie. Handbuch Neuraltherapie. München: Elsevier Inc (2010): 1052-4.


Weglein, Adam D. Neural prolotherapy. Patients 3, no. 2 (2011): 639-643.

Weinschenk, Stefan. Neural therapy – a review of the therapeutic use of local anesthetics. Acupuncture and related therapies 1, no. 1 (2012): 5-9.

Weinschenk, Stefan, Kerstin Brocker, Lorenz Hotz, Thomas Strowitzki, and Stefanie Joos. Successful therapy of vulvodynia with local anesthetics: a case report. Complementary Medicine Research 20, no. 2 (2013): 138-143.