For Love of Oxygen

For Love of Oxygen

August 28,  2020

For Love of Oxygen

By Dr. Heather Tallman Ruhm

Recently I have been thinking a lot about the element we call oxygen and its incredible roles in life at large and in our bodies and our internal organisms, our magnificent microbiomes. We

are obligate aerobes – we need oxygen to survive. Most of us know this intuitively. Generally, people can survive 2-3 weeks without food, 2-3 days without water, but only 2-3 minutes without O2.


Our food and water are made of oxygen including our major nutrients. The bulk of our edible fruits and vegetables is H2O – water is one-part Oxygen two-parts Hydrogen – the O part outweighing the H parts by about 8 times. Sugars, fats, cholesterol, and proteins all contain -O’s. Roots need aeration. Wild plants and crop foods do better when their soil is loose and accessible to oxygen. Hydroponics and aeroponics need oxygen too. One critical element in the food chain of this planet is indeed oxygen. Maybe this is just a profound glimpse into the obvious, none-the-less when I contemplate the magnitude of oxygen’s magical molecules, it gives me pause. It makes me want to celebrate O’s existence and protect it too.


Oxygen enters our lungs as O2 and leaves them as CO2. O2 enters plant bodies as CO2 and

leaves them as O2 (pun intended). Plants are made of oxygen and carbon and hydrogen and a

smattering of other elements and so are we. We need plants, they need aerobes. Animals eat

plants and breathe oxygen to stay alive and the cycle is complete. Years ago, I read Sherwin

Nuland’s book How We Die. It made me reflect on our MOA (mechanism of action) of death.

Our ultimate demise, in every case, was a lack of O2. Breath is the vehicle that brings life into

our bodies, delivering oxygen to our lungs and beyond. Remove it, deny access, and we’re

done in 2-3 minutes. Partially remove access and we suffer. In medical school, we had to suck

air through a little red-striped, hollow stir stick to empathize with someone suffering from

emphysema or an asthma attack.


From the outset of this current pandemic, the front-line doctors in NY reported on ill patients with high altitude symptoms, low O2, then breathlessness. This is what we fear. Oxygen is the great elixir of life. No one can imagine life without it, for obvious reasons. The current fear instilled in the minds of men and women, scientists, and laypersons alike is the fear of suffocation. Ironically, living in fear of losing our breath, and keeping our mouths partially covered, encourages shallow breathing and poor oxygenation at a time when we most need O2. We have been given reason to pause during this global pandemic/med-panic, and we should, if for no other reason than to reflect: 1) to appreciate the role of oxygen in our bodies, 2) to find ways to access more of its life-giving properties in our lives, and 3) to support approaches that relieve our deepest fears about losing it.


What are some practical approaches? We can eat plants rich in oxygen and anti-oxidants and make it a top priority to get out in our organic gardens and nature to exchange our breath with plants. We can practice increasing the length of our exhales which encourages deeper breathing and better O2 uptake. We can embrace physical activities that lower our stress and anxiety and put our minds in a more peaceful state. We can lower our carbon footprint and pollution too, by driving less and walking more. We can work on keeping our blood and bodies clean of contaminants to feed and foster our microbiome. When we don’t protect the bacteria that serve us, we get a preponderance of those that overwhelm us. Sometimes we forget the simple stuff: we need clean water, clean air, deep breaths, good food, more probiotics, and fewer potential poisons. This is what makes us youthful – oh yes, and sleep and movement and joy and creativity and oxygen and a little less fear.


Back to oxygen. Thousands of people are placed on blood thinners to assure adequate blood flow, to assure oxygen arrives to our brains and bodies, to prevent cerebral vascular accidents and myocardial infarcts (accidental strokes and heart attacks). No one wants to die this way. One large group that knows they are somehow at risk today is the diabetic population. When a medical professional suspects this condition or monitors it, we do so by measuring hemoglobin in the form of HgBA1C. When there is excess sugar in the blood for too long, it sticks to our hemoglobin. Hgb lives for about 120 days, it has a long time to accumulates these sticky hitchhikers. And when our blood is too sticky for too long, we can’t get oxygen to the far reaches of our arteries and capillaries, and they begin to suffocate. These are the bodies mini-strokes, as it were, that lead to low oxygen and tissue damage, even death.


Dr. Tom Cowan was the first person to introduce me to the idea that our hearts are not the true

source of the movement of our blood. Most people, myself included, were raised and taught to

believe that the almighty heart pump was the end-all, be-all to ones’ sanguine course. The

heart is a profound purveyor of life in many ways and clearly contributes to the flow of our

blood, but it is not the source of its movement. The movement begins as a keenly choreographed

dance in the most minute spaces, in the lungs and their tiny air sacs, in the smallest, most

delicate and narrow arteries and veins, the places where O2, CO2, Hydrogen and other gases

and nutrients are exchanged like currency to feed our cells and remove their garbage.


The movement begins in the chemistry, through our cell’s electrical membranes and their voltage

powered gates, that rely on potassium, calcium, sodium, H+ and O- in balance. The deep caverns and crevices of our roots made up of sophisticated cell surfaces form a critical marketplace for

the exchange of life’s basic elements and the source of blood mass migration. The stuff we offer our lungs and roots, the things we give permission to course through these portals of our existence, determine our health and its flow. Smoothness or stickiness is not just about sugar. When we are in fear, or chronically stressed, we release chemicals, and genetic material, and acids that speed our hearts and shrink or isolate our cells and cause immune reactions. When we harbor anger and resentment and shame or suppress our true feelings or host the chemical fallout of trauma in our bodily tissues, we change our chemistry. We change our energy.


Chemistry is energy or at least an electrical potential after all. The positive and negative

exchanges that take place at those nano surfaces of nutrient and waste exchange drives the

movement of our blood, but it also attempts to balance our pH (the acidity and alkalinity of

each cell and its surrounding soup). Several years ago, Dr. Jerry Tennant brought my attention

to something so beautiful and elegant about our physiology that I wish I knew it sooner. Maybe

we should just ponder its magnitude. The pH (the relative acidity or alkalinity) of a liquid be it

blood or water or battery fluid is just a translation of its voltage. It’s like saying house in

Spanish, French, or Swahili. Casa, la maison, and nyumba look different, but they share their

meaning. They just need a good translator: pH 7 = 0mV, pH 0 = +400mV, pH 14 = -400mV. Our

millivolts, our energy, tells the story of our access to oxygen and friends in a different language. I am grateful for teachers like Drs. Cowan and Tennant and others who have come before.


We can be grateful for scientists, like Dr. Otto Warburg a 1931 Nobel Prize winner, who showed

us the important role oxygen plays in our health, and we can learn from innovative

practitioners who have made great advancements in the field of brain injury recovery and

orthopedic repair (dealing with chronic ligament and joint trauma and inflammation). Their

work repeatedly demonstrates the reverse effect of “how-we-die-without-O2.” They watch

tissues heal before their eyes and see dramatic improvements in their patients when they are

able to deliver oxygen to otherwise deprived tissue. In his article in the Journal of Prolotherapy

| volume 3, issue 2 | May 2011, Dr. Schallenberger did a beautiful job of explaining how

prolotherapy and prolozone injections to joints and ligaments (low oxygen areas) which have

suffered from trauma relieve even longstanding suffering and allow for repair. He is able to

disrupt what he calls The Circle of Chronic Pain (trauma —> decreases oxygen utilization —>

decreases membrane potential and increases free radical damage —> increases tissue damage,

edema and inflammation) with these oxygen enhancing therapies.


By improving circulation, lowering inflammation, and increasing oxygen, tissues breathe a sigh of relief. If we support our microbiomes (which create many of the substrates needed in oxygen utilization), and improve lifestyle habits that encourage healthy blood flow, then we can replace much fear with hope.

Read any book or scientific journal on the benefits of breathing to move oxygen and it will not come as a surprise that when we move oxygen into our tissues we enhance our lives. Likewise, when we eat well and sleep well and move our inner worlds with intention when we take care of the chemical messages we share with our roots, our blood, brains, and bowels benefit, as does our beautiful biome.


There are many ways to bring oxygen to our lungs and support its transport and help move it in and out of our cells. The fetus may have the upper hand when it comes to an affinity for oxygen, but we all should be so covetous. We should be careful about the things that inform our chemistry and our electricity; which electrical interferences we allow to flow through our bodies while we face a computer screen or TV or hairdryer or any other “smart device.” We can improve our affinity to oxygen when we pursue practices that raise our pH and lower our electrical exposure. We can promote alkalinity through fresh foods, leafy greens, especially those rich in minerals and anti-oxidants, and through relaxation and exercise.


This is not new science; it is fundamental, yet should not be forgotten or taken for granted. Bioregulatory medicine is wise to improve our access to oxygen, and balance energy, and un-obstruct the flow of our blood and its correlate waste removal system, the lymph. We need to get un-stuck, releasing our visible and invisible scars, nourishing our vessels and cells and bugs, allowing our bodies to take in oxygen and let go of fear. Give O a chance, even for 2-3 minutes.

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The Five Elements and Ultimate Health

The Five Elements and Ultimate Health

June 30, 2020

The Five Elements and Ultimate Health

Ian Kennedy

In traditional thought of how the body functions and how we can view the self in a more bioregulatory way we can refer to the ancient understanding of the five elements. Water, Earth, Fire, Air and Space. We, like the earth are 72 percent water, 20 percent earth, 9 percent fire, 6 percent air and the rest, 3 per cent is space.


When we speak of the body and maintaining health in a bioregulatory way, water is the first and most important of all elements. Science today finally understands that water has an amazing capability to gather and hold information. This is new to science, yet has been known for eons by the ancients. This information is not held in a chemical way, but in a molecular way. Water picks up information from its surroundings and gathers information from what it is exposed to, from its source and along its pathway, to wherever it may be migrating from and finally arriving to. When water is being pumped from a source through pipes, that lets say has, thirty-five bends in it, the water is changed molecularly. It is also being forcibly pushed through the piping which also creates a certain memory within it. Now it arrives at your home. What if you are living on the twelfth floor of an apartment building?  It also must be forced up through more pipes to reach your tap. If you go to the tap and just drink this water – much of it – let us say 60 percent will act like a poison in the system, not chemically but molecularly. One hundred and fifty years ago or more when water was gathered from springs or wells it was taken into the home and was not immediately consumed. It was placed in a clean vessel often with a flower atop it and would sit that way overnight. If water is given some time to settle down it will return to its purer state and will not hold the information that it gathered previously. Now it will be suitable for consumption. Handling our water in this way and consciously infusing our water with positive thoughts, and holding a certain reverence for it, will greatly enhance its effects on our body. Water should also be drank only when one is thirsty. Sipping water all day dramatically lowers the sodium levels in our body and this combined with a flushing out of needed minerals from the system causes many health issues such as foggy brain and fatigue. Taking great care of our water will help take care of our body and our overall health in a profound way. Next comes earth. It is our food that represents the earth element within our body. It Is our food that comes from the earth and this twelve percent is still a significant part of our well-being and our health. Foods that have a high content of water are best to be consumed. Plants and fruits have the highest percentage of water within them. The less they are cook the better. It is also important in how the food is handled, prepared and by whom this task is done. Since these foods have a high content of water they also have the ability to retain information. Meat, bread, cheese and more processed foods have a lower percentage of water and generally have less nutritional value. Taking care of the preparation and presentation of our food, as well as giving thanks for it and having reverence for the life that has been taken to support our own, will greatly enhance its worth to our body. It is also greatly beneficial to get our hands and bare feet into the soil. This helps us reconnect with this element and receive microorganisms that are beneficial to our gut function.   Then there is fire. The fire is 9 percent of the system and can been our emotions as well as our metabolism. Are our emotions those of greed, anger, hatred, jealousy, or exclusiveness? Or are they the fires of love, joy, compassion, and inclusiveness? Our emotions are the fire that burns within us. Another way of understanding the fire element is the sun. The sun is the greatest fire we are exposed to and it is pure and unpolluted. It is life sustaining since all energy and all food is solar powered in some way.  Getting sun on the body every day is greatly beneficial to our overall well-being and our physical health. Early morning and late afternoon sun are healthy to expose ourselves to and it is also good for our circadian rhythm to gaze at the sun as it rises and as it sets. This will keep us in tune with the fire element within us. Finally there is air. Air is much more than just our breath. Air is within every cell of the body. Every cell is 6 percent air.  Without air or the oxygen that we gather from it our cells, muscles and brain will not work efficiently. Today much of the air has become artificial or polluted. Indoor air is often air conditioned and tends to be more stagnate than outdoor air. If we are living in big metropolitan areas this cannot be avoided since the outside air often has smoke, dust, chemicals, and smells in it. Since air however is only 6 percent of the body element however it is less important than our water when it comes to our health. This is not to say that we should refute its value. The best thing to do is to get out into the woodlands or forest, or along a beach and take in good pure air that the earth has circulated. Lastly there is space. This is but 3 percent -for some such as our politicians it may be more – usually residing in the skull. The concept of space is for the esoteric and its importance is vital. Having space to be and think is critical to our mental health. Being confined ether physically or emotionally will cause many unhealthy issues for human beings since we are creatures that always seek expansion. Human beings need space and it is only within space that we can exist it. Though it is only 3 percent without it we could not take on this physical form.


Living a bioregulatory lifestyle one cannot ignore the value and direct connection we have to the five elements. By understanding their multi-dimensional balance it provides us with the power to enhance our health and our lives.      

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BRMI Recommended Book: Plague of Corruption: Restoring Faith in the Promise of Science

BRMI Recommended Book: Plague of Corruption: Restoring Faith in the Promise of Science

May 4, 2020

BRMI Recommended Book: Plague of Corruption: Restoring Faith in the Promise of Science

Book authors Judy Mikovits & Kent Heckenlively

The Bioregulatory Medicine Institute (BRMI) examines science as a cornerstone of our institute, often to find that it has been manipulated, leading people to hold misconceptions in regards to health and healing. As we endeavor to bring a Renaissance of health through bioregulatory medicine, and the science of self-healing, we recommend this book to shed light on both the corruption and promise that is found in the truth.


“One of the main problems of our time is the public loss of confidence in the scientific community because of a too often corrupt coalition of governmental and corporate entities.Judy Mikovits’s and Kent Heckenlively’s book delves into the midst of this rampant corruption, which hides  from the public scientific truths which might go against these corporate economic interests.”


Dr. Luc Montagnier, 2008 Nobel Laureate for the isolation of the HIV retrovirus


From Amazon: “Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys’ club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried.


From her doctoral thesis, which changed the treatment of HIV-AIDS, saving the lives of millions, including basketball great Magic Johnson, to her spectacular discovery of a new family of human retroviruses, and her latest research which points to a new golden age of health, Dr. Mikovits has always been on the leading edge of science.


With the brilliant wit one might expect if Erin Brockovich had a doctorate in molecular biology, Dr. Mikovits has seen the best and worst of science. When she was part of the research community that turned HIV-AIDS from a fatal disease into a manageable one, she saw science at its best. But when her investigations questioned whether the use of animal tissue in medical research were unleashing devastating plagues of chronic diseases, such as autism and chronic fatigue syndrome, she saw science at its worst. If her suspicions are correct, we are looking at a complete realignment of scientific practices, including how we study and treat human disease.


Recounting her nearly four decades in science, including her collaboration of more than thirty-five years with Dr. Frank Ruscetti, one of the founders of the field of human retrovirology, this is a behind the scenes look at the issues and egos which will determine the future health of humanity.”


The foreward of the book is written by Robert F. Kennedy, Jr. with these words: “This account by Judy Mikovits and Kent Heckenlively is vitally important both to the health of our children and the vitality of our democracy. My father believed moral courage to be the rarest species of bravery. Rarer even than the physical courage of soldiers in battle or great intelligence. He thought it the one vital quality required to salvage the world. If we are to continue to enjoy democracy and protect our children from the forces that seek to commoditize humanity, then we need courageous scientists like Judy Mikovits who are willing to speak truth to power, even at terrible personal cost.”


About the Authors


Judy Mikovits, PhD, spent twenty years at the National Cancer Institute, working with Dr. Frank Ruscetti, one of the founding fathers of human retrovirology, and has coauthored more than forty scientific papers. She co-founded and directed the first neuroimmune disease institute using a systems biology approach in 2006. Dr. Mikovits lives in Southern California with her husband, David”


Kent Heckenlively, JD, is a former attorney, a founding editor of Age of Autism, and a science teacher. During college Heckenlively worked for US Senator Pete Wilson, and in law school he was a writer and an editor of the school’s law review and spent his summers working for the US Attorney’s Office in San Francisco. Kent and his wife Linda live in Northern California with their two children, Jacqueline and Ben.”

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Life is Cyclical

Life is Cyclical

April 30, 2020

Life is Cyclical

Ian Kennedy

The Bioregulatory approach embraces the fact that life is cyclical. This is not merely the concept that we are born, die, and are recycled. This construct gives us a template to follow throughout our lives – that we are meant to be aligned bio-rhythmically to our world and universe- guiding us to optimal health and vitality. 


What happens that eventually leads one to illness? It is when we become disconnected from source – falling out of healthy cyclical patterns. Changes accrue, and what we once experienced as wellness is eventually experienced as sickness. What must happen to reverse from illness back to wellness? A cycle of health must take place.


When life begins there is a natural coherence that binds us to all life-related cycles. We experience life based on the alignment of the geometry within the universe and within us. We experience life based on the alignment of the geometry within the universe and within us. If the universe had a different geometry the human experience may have ceased to exist. As living beings we thrive because of this celestial geometry: the sun, the moon, and the earth.


The cycle of the moon is responsible for all human life. Without our mothers’ natural menstrual cycle, none of us would exist. The moon pulls on the oceans creating tides and on the cerebral fluid in our brain and spinal cord. We are closely connected with the moon.


The sun and our reliance upon it are also part of creation. Everything is solar powered. Every morsel of food you have ever eaten has been produced by the sun. When you eat meat, the cow that you feed upon has received its life energy from the grass, which utilizes the sun’s life energy. Every carrot and potato is produced by the sun’s energy.


There is also our bond with the earth, which is an intimate one. Not only does our food and water come from it, but our very breath connects us to it as well. The Earth is divided into latitudinal lines running around the planet. The equator is 365 degrees and runs around the middle circumference. Each degree of the line is divided into minutes. Each minute represents one nautical mile. The Earth is 21,600 nautical miles at the equator and spins at one thousand miles per hour. If a person is of relatively good health their resting heart rate will be 15 respiration’s per minute. That is 900 breaths an hour which equates to 21,600 breaths per day, equaling the number of nautical miles around the center of the earth.


Restoring a person’s natural cycles is as important as suggesting the correct diet or providing the correct remedy. It is easy to fall out of healthy natural cycles today with the constant exposure to Wi-Fi, other modern man-made toxic loads, our ability to overwork, overeat and sleep inappropriately, as well as alcohol, drug use, and other compulsive behaviors. Other signs of the loss of our natural cycles include: Insomnia, restlessness, poor elimination, lethargy, apathy, lymphatic swelling, emotional eating and other emotional imbalances; including anxiety and depression. Cycle loss is a sign of inertia affecting the physical, mental, emotional and energetic bodies.


Inertia in the body brings us close to the experience of death. There are some things that contribute to inertia, and, in this context; inertia refers to the loss of the natural motion of energy through the body. Food void of life energy will bring certain inertia to the body. Processed cooked foods are lacking in life energy to the body. When non-living food is consumed a person often feels tired or sluggish. When we feed the physical body in this way, there will also be inertia build up in the mind, emotions and energies of a person. Illness always has a component of inertia to it, such as when the lymphatic fluid thickens, and lymph nodes swell. When the lymphatics become stagnant that makes for sluggish detoxification, a sign of more inertia. Death is the final form of inertia for any living being. From the nervous system’s lack of responsiveness to the loss of mind function, to the setting in of rigor mortus within the body, inertia becomes final. 


Therefore, if inertia is a sign of illness and death, responsiveness and movement is a sign of life and health. Movement is youthfulness and has little to do with age. Effective circulation (movement) of our blood and lymph is a symbol of well-being. We all know that constipation is an invitation to illness. Therefore, having a good digestive cycle is a sign of health. A natural sleep cycle is a sign of health. The loss of any cycle is a sign that there is a possibility of dis-ease setting in. If we don’t move the physical body, it stiffens. This is evident in the morning for those who wake with stiffness in the body. Their natural lubrication has settled in the joints and needs to be recirculated through movement of the body. Without lubrication, there is friction, and there is pain and wear wherever there is friction in the body. This can be applied to all aspects of life. The physical body, relationships, business, emotional wellness, and mental and spiritual well-being all require a certain amount of lubrication and movement to remain vital in our lives. If there is no lubrication, there’s friction, and if there’s friction, there’s a loss of flexibility and movement, and without movement nothing happens, so nothing can be done except to create more friction and inertia.


Health, like life is not sedentary. Life and health require movement. The more free the movement we experience in body and mind, the more flexible we can become, and the more flexible we become, the more possibilities open to us. How are we going to help people regain their natural cycles and the lubrication need to move towards heath and a life with less friction? First, there must be willingness. If there is willingness to change the diet, activity, remedy, outlook or any other shift needed than restoring health and well-being will become easier. If a certain level of willingness is not present, then change will be impossible regardless of what may be given or suggested. When we are willing, we naturally experience a certain level of openness, and that is the beginning of change. If what we do is done unwillingly, then we experience unpleasantness and that is the very bases of dis-ease. It is well understood that certain emotions stimulate certain chemical reactions within the body and those can create conditions that support health or invite illness. If there is willingness everything becomes easier. When there is unwillingness even the simplest things become difficult or unbearable. 


Some simple steps to help reset natural cycles can be as easy as: Sleeping in complete darkness except for the night before, the night of and the night after the full moon. On those nights it is best to allow the moonlight to come into the bedroom. This can help reset our circadian rhythm. Take a few minutes at twilight and watch the sun go down. This will help with the production of the hormone’s serotonin and melatonin. Moon gaze to promote and maintain a natural circadian rhythm. It can also help set a romantic mood, stimulating another important rhythm to the body. Turnoff the Wi-Fi router at night to reduce the number of disruptive radio waves that stimulates brain activity. Make a conscience effort to be among nature, walk in the woods. Get sunlight on your face and forehead this helps with vitamin D production in the body. Eat less food. In adulthood for most it is beneficial to eat less than we do. Today, almost seventy percent of Americans are considered obese. And sadly, seventy percent of Americans are on prescription medications. Having at least eight hours between meals is valuable in not over stressing the digestive system. It has also been found that unhealthy cells find it hard to survive when a person eats in this way. Eating the first meal in the morning and then eating again just after the sun goes down has many health benefits. This is not problematic if the food consumed is live and energetically vital. Going to bed hungry takes a little getting used to, but this practice also has many positive health benefits. Consume water. Our body is seventy-two percent water. Every cell needs water to function, and water is vital for detoxification and elimination. Finally, don’t forget to move. Movement is health, and balancing an inactive lifestyle with movement is vital in maintaining proper functioning. Walking, swimming, yoga and other low impact activity keeps the body flexible. Flexibility is a sign of youthfulness. Embrace the natural cycles that make life dynamic, and you will find that health is a natural consequence to staying in rhythm with the natural cycles of life. Finally, take time to do nothing. Our lives are filled with activity and having time to do nothing will also restore some balance to an individual. Take one day a month and go dark. No talking, no screens of any kind. No cell phone, computer or T.V. No book to read either. Be alone for twenty-four hours without any external artificial stimulation.


Cycles are a healthy aspect of life. Staying in touch with our cycles and how they link us to life not only creates health, but also a full, balanced and joyful experience.

Ian Kennedy, BRMI Advisor

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Uniquely Human

Uniquely Human

Febuary 7, 2020

Uniquely Human

There are a few structures in the body that make us uniquely human – two of which are our pelvis (which derives its uniquely human form and function from the fact that we are bipedal, upright walking organisms) and – our teeth.

Our teeth, including our dental arch (the shape of our upper palate and jaw) have been directly influenced through the evolution of the foods we’ve consumed. This evolution continues today.

Human teeth are the strongest substance in the body, much stronger than bone. They begin to form approximately 6 weeks after conception. Excluding the wisdom teeth, the normal adult has 32 teeth (16 on both the upper and lower jaws), which typically erupt by age 13: 4 incisors (front teeth), 2 canines (which flank the incisors), 4 premolars, and 6 molars (which extend to the back of the mouth).

Our 4 wisdom teeth typically emerge around age 18, but as we evolve, it is becoming more common to see individuals who have never had wisdom teeth at all. It is believed that this is an evolutionary adaptation due to changes in our diet. Modern man now lives on a diet of soft foods. Unlike our ancient ancestors, we no longer need to crack open bone for its marrow or grind up nuts and roots for food, rendering wisdom teeth unnecessary.

When wisdom teeth do come in, they are often surgically removed due to space issues. If this procedure is performed incorrectly (which often it is), it can lead to cavitation infections within the jawbone where the tooth once resided. This will inhibit bone growth and the resulting infection will persist for years without symptoms. Unbeknownst to the individual, it puts stress on the body’s immune response, most often to the point of collapse.

Cavitations, from a bioregulatory perspective, are one of the underlying and often undiscovered issues for those who cannot seem to regain their health or maintain proper regulation. Clinically, if someone undergoing therapy at our center does not experience a significant positive shift within 3 months, it is almost always due to a dental/oral issue, acting as a blockade to the natural healing process.

As a result, our bioregulatory approach takes into consideration not only possible cavitations, but also each tooth and its association to related organs, body systems, joints, vertebra and acupuncture meridians. This evaluation has made a big impact regarding the wellness achieved with each of our clients. The distal stress placed on the body by the teeth and oral cavity is remarkable. If oral health is ignored by either the practitioner or the client, then complete and lasting healing with a positive outcome is doubtful.

Another point of major concern are root canals, which are achieved by drilling out the root of the tooth, effectively disconnecting it from the central nervous system. This produces a dead tooth, a virtual cadaver in the mouth. This “dead” tooth can act as a reservoir for microbes that may reproduce and migrate to other areas of the body, causing illness and further stress to the immune system in much the same way a cavitation site does. Dr. Thomas Rau, former Medical Director of the Paracelsus Klinik in Switzerland, has noted that almost all breast cancer patients he has treated have had root canaled molar teeth. Interestingly, in Traditional Chinese Medicine, these molar teeth are seated on and connected to the stomach meridian. The stomach meridian passes directly through the center of the breast as it travels along its pathway.

Now, it is not believed that the root canaled teeth had anything to do with the manifestation of breast cancer directly; rather it was shown through biopsy that the same microbes within the breast cancer were appearing in the root canal area of the tooth. This migration, if left undetected, leaves the woman who may have survived breast cancer with the potential of having the same microbes disperse from the root canal through the bloodstream – potentially reinfecting the woman in the future. In the case of autoimmunity and other degenerative diseases such as cancer, MS, ALS, Parkinson’s disease etc., or if regaining one’s health has become a struggle, it is always wise to investigate the dental/oral condition.The bioregulatory approach to root canals is to have them appropriately extracted by a biological dentist who can ensure that cavitation infection will be avoided.

It is very clear within the community of bioregulatory-trained medical doctors and practitioners that “sick” teeth contribute to illness and disease and, at the very least, strain the immune system. The care of our teeth and our mouth’s microbiome is vital to long-term good health.

Case study verifying the importance of oral/dental health in regard to symptoms of a recurring bladder infection

A few years ago, a client came to us experiencing the symptoms of a bladder infection. She had been involved with bioregulatory therapy at our center for a few years, and wished to address her symptoms without the use of antibiotics. Upon investigation, we discovered that she had been symptomatic for the previous 4 weeks. She requested remedies that had worked well in the past and out the door she went.

One week later, she returned and unlike her past recovery, reported that she was still suffering. At this point, 5 weeks had passed and her symptoms seemed to be getting worse. We asked if anything had changed a week or two preceding the onset of symptoms. She thought for a moment, and told us that her dentist had been working on a tooth to change her bite and that he had done so on consecutive visits. When I asked which tooth he had been working on, she pointed to her 2nd incisor, tooth #26. This tooth is associated with the bladder meridian. I had her reach up and hold the tooth and apply a slight twisting pressure from the outside to the inside, as I performed a simple muscle test (applied kinesiology). Her system was unable to maintain a locked muscle, yet when she applied pressure from an inside to outside direction her ability to lock her muscle returned. I suggested she go back to her office and every 15 minutes reach up and apply slight pressure to the tooth in that direction. By 3 o’clock that afternoon, after doing nothing more than applying a little manual pressure in one direction to the tooth, all her bladder infection symptoms had resolved.

Without taking into account the bigger picture and only following her symptomatology, she very well may have ended up on antibiotics and most likely lacking positive results for her bladder discomfort. By stepping back and investigating what was happening weeks before her symptoms presented, and through the understanding of the connection between our teeth, organs, and meridians, her symptoms were relieved with a simple solution.

Within our bioregulatory approach, we always take note that distal symptoms can very easily be created by dental work. Our relationship with our client is key – as is maintaining open communication regarding treatments they receive elsewhere.

Today we not only investigate a person’s oral/dental situation when we first meet – we also stay informed as to their plans for any future dental work. We of course prefer and recommend only biologically trained dentists. We continually communicate with the dentists and educate the client to ensure we are setting everyone up for successful outcomes.

Educating the public about the connection between our health and our teeth is both challenging and rewarding. But most importantly, incorporating a well trained biological dentist into your healthcare team will not only help maintain healthy teeth and a healthy oral microbiome, but will also support us in following a bioregulatory lifestyle.

Ian Kennedy is the Founder and Head Clinician of The True Wellness Center in Pennsylvania.

#biologicaldentistry #toothmeridians #interactivetoothmeridianchart #oralmicrobiome #rootcanals

Recent Posts

Starred Review for New Book on Bioregulatory Medicine!

Starred Review for New Book on Bioregulatory Medicine!

Febuary 7, 2020

Starred Review for New Book on Bioregulatory Medicine!

“Bioregulatory Medicine turns the American healthcare system on its head for the benefit of individuals’ health.”

Promising to take the medical world by storm, a new book on Bioregulatory Medicine has received a starred review from Foreword, one of the industry’s premier trade review media.

The book, Bioregulatory Medicine: An Innovative Holistic Approach to Self Healing, is authored by no fewer than 4 BRMI Advisors: Dr. Dickson Thom, Dr. James Odell, Dr. Jeoffrey Drobot, and Dr. Frank Pleus – along with Jess Higgins Kelley, MNT (co-author of The Metabolic Approach to Cancer).

To pre-order the book (which will be released on November 2), click here.

For the full review from Foreword Reviews, click here.

Recent Posts

Schumann Resonances and their Effect on Human Bioregulation

Schumann Resonances and their Effect on Human Bioregulation

Febuary 7, 2020

Schumann Resonances and their Effect on Human Bioregulation

The Schumann resonances (or frequencies) are quasi-standing electromagnetic waves that exist in the cavity (or space) between the surface of the Earth and the ionosphere. In 1952, German physicist Professor Winfried Otto Schumann of the Technical University of Munich began attempting to answer whether the Earth itself has a frequency – a pulse. His assumption about the existence of this frequency came from his understanding that when a sphere exists inside another sphere, electrical tension is created. Since the negatively charged Earth exists inside the positively charged ionosphere, there must be tension between the two, giving the Earth a specific frequency. Through a series of calculations, he was able to deduce a frequency he believed was the pulse of the Earth-ionosphere space. Two years later, in 1954, Schumann and Herbert König reported reliable and predictable frequencies in the atmosphere that existed in the cavity (or space) between the surface of the Earth and the ionosphere. Though several frequencies occur between 6 and 50 cycles per second, the fundamental frequency they found to be 7.83 Hz.1

This “cavity” is naturally excited by energy from lightning discharges and radio atmospheric signals or sferics. (A sferic is a broadband electromagnetic impulse that occurs as a result of natural atmospheric lightning discharges.) This causes the Earth-ionosphere cavity to “ring” like a bell at specific frequencies, resulting in peaks in the noise spectrum. Schumann resonances are not measurable all the time but have to be “excited” to be observed. They are primarily related to electrical activity in the atmosphere, particularly during times of intense lightning activity. At any given moment, about 2,000 thunderstorms roll over Earth, producing some 50 flashes of lightning every second. Each lightning burst creates electromagnetic waves that begin to circle around Earth captured between Earth’s surface and a boundary about 60 miles up. Some of the waves – if they have just the right wavelength – combine, increasing in strength, to create a repeating “atmospheric heartbeat” known as Schumann resonance. This resonance provides a useful tool to analyze Earth’s weather, its electric environment, and to even help determine what types of atoms and molecules exist in Earth’s atmosphere.2

Lightning photo courtesy of NOAA Photo Library, NOAA Central Library,

OAR/ERL/National Severe Storms Laboratory (NSSL)

The waves created by lightning do not look like the up and down waves of the ocean, but they still oscillate with regions of greater energy and lesser energy. These waves remain trapped inside an atmospheric ceiling created by the lower edge of the “ionosphere” – a part of the atmosphere filled with charged particles, which begins about 60 miles up in the sky. In this case, the sweet spot for resonance requires the wave to be as long (or twice, three times as long, etc.) as the circumference of Earth. This is an extremely low frequency wave that can be as low as 8 Hertz (Hz) – some 100,000 times lower than the lowest frequency radio waves used to send signals to an AM/FM radio. As this wave flows around Earth, it hits itself again at the perfect spot such that the crests and troughs are aligned. Thus, waves act in resonance with each other to pump up the original signal.3, 4

The ionosphere is part of Earth’s upper atmosphere where extreme ultraviolet and X-ray solar radiation ionizes the atoms and molecules thus creating a layer of electrons. It stretches from approximately 60 miles above the surface of the Earth to the edge of space. Other phenomena such as energetic charged particles and cosmic rays also have an ionizing effect and can contribute to the ionosphere. This dynamic region grows and shrinks (and further divides into sub-regions) based on solar conditions and is a critical link in the chain of Sun-Earth interactions. Due to spectral variability of the solar radiation and the density of various constituents in the atmosphere, there are layers created within the ionosphere, called the D, E, and F-layers. The electron density is highest in the upper, or F region and this region exists during both daytime and nighttime. During the day it is ionized by solar radiation, during the night by cosmic rays. The D region disappears during the night compared to the daytime, and the E region becomes weakened. Highly charged ions and free electrons fill the ionospheric layers creating a “spectral power station”. Schumann frequencies are determined by the size of the Earth-ionosphere cavity and can vary slightly from a variety of other factors, such as solar-induced perturbations to the ionosphere, which compresses the upper wall of the closed cavity.5

When a solar flare occurs, the flare’s X-ray energy increases the ionization of all the layers, including the D layer. Thus, D now becomes strong enough to reflect the radio waves at a lower altitude. So, during a solar flare, the waves travel less distance (bouncing off D instead of E or F). The signal strength usually increases because the waves don’t lose energy penetrating the D layer. However, the strength of very low frequency waves (radio frequencies in the range of 3 to 30 kilohertz) can either increase or decrease during a flare. The signal strength could decrease because the lower the waves reflect, the more collisions, or interferences of waves, there will be because of the thicker atmosphere. These wave collisions can result in destructive interference.

Scientists had thought Schumann resonance was confined within the atmosphere and could only be observed from the planet’s surface. Using NASA’s Vector Electric Field Instrument (VEFI) aboard a U.S. Air Force satellite, scientists recently discovered that energy from the resonance sometimes leaks beyond Earth and can be detected from above, providing a new tool to analyze the chemical and physical makeup of the atmosphere.

Much of the research in the last 20 years has been conducted by the Department of the Navy, which investigates Extremely Low Frequency communication with submarines. Today Schumann resonances are recorded at many separate research stations around the world. The sensors used to measure Schumann resonances typically consist of two horizontal magnetic inductive coils for measuring the north-south and east-west components of the magnetic field, and a vertical electric dipole antenna for measuring the vertical component of the electric field. Specialized receivers and antennas are needed to detect and record Schumann resonances.

Though 7.83 is considered the fundamental Schumann resonance, other frequencies occur between 6 and 50 cycles per second; specifically 7.8, 14, 20, 26, 33, 39 and 45 Hertz, with a daily variation of about +/- 0.5 Hertz (Hz) These frequencies function as a background frequency influencing the biological circuitry of much of the life on Earth. The amount of resonance fluctuates as the ionosphere becomes more or less dense, which depends largely on the amount of solar radiation striking it. Another influence is that the world’s three lightning hotspots – Asia, Africa, and South America – also follow a day/night cycle and are seasonal as well. Thus, the peaks of radio signal strength at the Schumann resonance follow a constantly shifting, but reasonably predictable, schedule.

Schumann himself was interested in the biological effects of sferics in general, and his student – and later colleague – Herbert König continued his work. Schumann and König’s research revealed relationships between Schumann resonances and life on Earth. Their research spans from an influence on yeast cells and bacteria as well as plants and animals to humans.

Herbert König, who became Schumann’s successor at Munich University, discovered and further demonstrated a clear link between Schumann resonances and brain rhythms. He compared human EEG recordings with natural electromagnetic fields of the environment and found that the so-called alpha waves during brain activity lie in the same frequency range as the first two modes of the Schumann resonance. He speculated that this is possibly no coincidence, but a human adaptation to the electromagnetic environment over the long course of evolution. In this border area between physics, biology and medicine there are perhaps still interesting results forthcoming.6, 7

König and his colleagues described the remarkable similarities of spectral power density profiles and patterns between the Earth-ionosphere resonance and human brain activity which also share magnitudes for both electric field and magnetic field components. Since then, the phenomenon that brain rhythms may overlap and become synchronous with ultra-low frequency electromagnetic activity occurring within this resonant cavity has been observed and reiterated by other scientists.8, 9, 10

To test direct synchrony between magnetic processes occurring in the Earth-ionosphere cavity and the human brain, Saroka and Persinger measured simultaneously the Schumann resonance and brain electrical activity of a single individual who was sitting quietly outside with eyes-closed.11 Results of the analysis indicated the presence of transient periods of “harmonic synchrony” that appeared when cross-channel coherence was computed between the caudal root-mean-square signal derived from the brain and the extremely low frequency magnetic activity occurring in the proximal environment. These periods of harmonic synchrony lasted approximately 200 – 300 msec and consisted of simultaneous coherence within the 7–-8, 13–14 and 19–20 Hz bands. The coherence magnitudes were like those reported earlier by Pobachenko and colleagues.12

All behaviors, including consciousness, are generated by and correlated with brain activity. The activity can be conceived as complex matrices of electromagnetic patterns and their associated chemical changes. Weak intensity complex magnetic fields generated by the Earth and by human technology affect consciousness and experience. The critical factor is not the intensity of the fields, but their patterns and the information contained within the patterns. Those patterns that are most like the natural temporal configurations of brain activity are most effective.

— Michael Persinger13

Biophysics now suggests that our biological systems are tuned into the background frequency of our planet via the Schumann resonances. Since this first discovery, more scientific research has posited that Schumann resonances are very important electromagnetic standing waves influencing biological oscillators within the mammalian brain. A living system has many similar resonant frequencies due to their degrees of freedom, where each can vibrate as a harmonic oscillator supporting the progression of vibrations as waves that move as a ripple within the whole system.14, 15

The first five Schumann resonances overlap with the brain frequency bands or waves. Brain waves are grouped according to their frequencies and are labeled with Greek letters. Their most common frequencies include delta, theta, alpha, and beta.

Delta: 0.5 – 4 Hz This brain rhythm occurs in a deep dreamless sleep or unconsciousness. This is associated with drowsiness.

Theta: 4 – 7 Hz This brain rhythm is associated with drowsiness. It also occurs at the first stage of sleep and during deep meditation, when we are awake but open to mental imagery. It has been associated with creativity, intuition, daydreaming and fantasizing. It is believed to reflect activity from the limbic system and increased activity is observed in anxiety, behavioral activation and inhibition.

Alpha: 7 – 12 Hz This is the major rhythm seen in a normal, relaxed adult. It is present during most of life. It is considered a common state during alertness but not actively processing information. Alpha has been linked to creativity (creative people show alpha when listening and coming to a solution) and mental work. Alpha activity is also associated with overall mental and body/mind coordination, calmness, alertness and learning.

Beta: 12- 30 Hz Beta reflects highly active processing. It occurs during normal waking consciousness and outward attention. Slow beta: 12-17 is normal information processing and mental activity; Fast beta: 17-30 is heightened alertness and fight or flight, or anxiety.

Gamma: 30 – 100 Hz This is associated with waking states and can occur when we are simultaneously processing information in both brain hemispheres. Whales and dolphins also operate in these frequencies.

Resonance and Entrainment

Quantum physics has shown that everything in the universe vibrates and resonates with a unique frequency. Resonance occurs when a given system tuned to a certain frequency begins to oscillate or amplifies the presence of a preferential external frequency. Those frequencies that maximize or amplify a given object tuned to a specific frequency are called resonant frequencies. Together, two frequencies have the power to influence each other, if both are tuned in concordance for resonance. Simply put, one vibrational frequency can harmonize with another. If, for example, you strike a tuning fork of 100 cycles per second and bring it near another tuning fork of that same frequency, the second tuning fork will be set in motion. Even though it has not been struck, the second fork will begin to vibrate and radiate a sound merely by being in the same field as the vibrating tuning fork. Like the tuning fork example, evidence shows it is possible for the brain to detect, tune into and respond to a Schumann resonance signal. Another example of resonance is demonstrated when a singer breaks a glass by singing at a certain pitch. The frequency of that tone matches the natural frequency of the glass, shattering it.

Entrainment is the process whereby two interacting oscillating systems, which have different periods when they function independently, assume a common period. The two oscillators may fall into synchrony, but other phase relationships are also possible. The system with the greater frequency slows down, and the other speeds up. In other words, one vibrational frequency can tune the other, train it into harmony. It is more than plausible that humans and various Earth life forms are tuned or resonate to these Schumann vibrations of Earth-ionosphere cavity. Research in Russia has also confirmed this phenomenon.16, 17

Alterations of the Schumann Resonances

Schumann frequencies have wrapped life on Earth since its inception. Atmospheric electric discharges generate broadband electromagnetic waves that propagate between the surface and the ionosphere. These two layers define the surface‐ionosphere cavity, which supports two types of electromagnetic modes: (i) longitudinal modes corresponding to global, quasi‐horizontal wave propagation around the globe and (ii) transverse modes related to local, quasi‐vertical propagation between the surface and the ionosphere.18

Driven by lightning, and affected by solar flares, these primal Schumann resonance pulses are thought to calibrate us and enhance our physical and mental well-being. That natural resonance helps us achieve our optimal brainwave states, but this atmosphere-to-human linkage has been recently disrupted by the electrosmog of much of today’s technology.

Several human reaction-time experiments have been conducted relative to Schumann resonances. König showed that human reaction times were significantly correlated with the intensity of the 8-10 Hz Schumann signal. Ten (10) Hz has been shown to speed up physiological reaction times, while 3-Hz signals from local thunderstorms have been shown to significantly lower reaction times. This phenomenon can be demonstrated by changes in EEG patterns and calcium ion uptake in the brain.

Research carried out by E. Jacobi at the University of Düsseldorf showed that the absence of Schumann waves creates mental and physical health problems in the human body.19 Following up on this research, Professor R. Wever from the Max Planck Institute for Behavioral Physiology in Erling-Andechs began a study where he built an underground bunker that completely screened out magnetic fields. He then had student volunteers live in the bunker for four weeks, where they were hermetically sealed in this environment. Throughout the four weeks, Professor Wever noted that the student’s circadian rhythms diverged and that they suffered emotional distress and migraine headaches. Considering that they were young and healthy, no serious health conditions presented – which likely would not have been the case with older people or people with compromised immune systems. Wever then added the Schumann frequency back into the environment and the results were astonishing. After only a brief exposure to 7.8 Hz (the frequency which he had been screening out), the volunteers’ health stabilized.20

Thus, it seems that the extremely low frequencies (6 to 30 Hz), and corresponding wavelengths of 100,000 to 10,000 kilometers, respectively of the atmospheric electrical discharges, operate as a stimulus for the human/animal brain electrical activity and thus they constitute a very significant part of the animals’ biological clock in addition to the diurnal light-dark cycle in the terrestrial environment. This is in complete agreement with the Wever (1979) experiments. Moreover, remarkable similarities of analogue characteristics between sferic EMFs and axonal action potentials in animal brain nerve cells have been reported.

Electrosmog’s Effect on Schumann Resonances and Life on Earth

Research within the last several decades demonstrates that alterations in geomagnetic activity from man-made electromagnetic technology – “electro-smog” – have caused significant changes in the intensity and stability of the Schumann resonance. Telecommunication technology operates within the Earth’s ionosphere cavity and these artificial signals can influence and even change the Schumann resonance to flux outside its normal spectrum. This in turn can potentially induce alterations in the normal resonance with many Earth life-forms, particularly influencing brain rhythms and human physiology synchronization.

Electrosmog exposure has been shown to cause many different physiological pathologies.21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 All appliances, computers, TV’s, cell phones, radios, digital devices, air conditioners, lighting, power lines, communication lines, air waves, radio waves, etc. produce electromagnetic fields that can be disrupting to our own biofrequencies. These electromagnetic frequencies either from above – interrupting our link with the Earth-ionosphere resonance – or from direct exposure, can interfere with the body‘s electromagnetic operating system.32

Thus, many scientists conclude that the Schumann Resonance is already being altered by all the radiofrequency/microwave “electrosmog” radiation humans are presently creating, and the implementation of 5G will alter it significantly more. In the process, whether or not it is raising the Schumann Resonance frequency, 5G may also be creating enough electropollution noise to be disconnecting humanity from accessing the Schumann Resonance itself – thereby creating and/or amplifying a variety of acute and chronic disease conditions.

Research in the last 30 years shows that ELF electromagnetic fields affect the way calcium ions move in brain tissue and the way this affects the cells’ inner workings. The more permeable the blood/brain barrier, which will happen with 5G, the greater the amount of toxins that can enter the brain. The opening of the blood/brain barrier and calcium leakage is also associated with oxidative damage to neurons and can damage the DNA structure.33, 34

All of this is already associated with electrosmog, dirty electricity, electrical pollution, and electrical hypersensitivity, which is seen in many patients.

5G frequency is connected to the 60 GHz millimeter-wave band. Thus, 5G applications will require the unlocking of new spectrum bands in higher frequency ranges above 6 GHz to 100 GHz and beyond (5G is to start initially with sub-6GHz moving as quickly into 6GHz and above as the network advancement allows). This will allow the utilization of sub-millimeter and millimeter waves to allow ultra-high rates of data to be transmitted in the same amount of time as compared with previous deployments of RF/MW radiation. 5G represents a massive step up from 3G at 1.8-2.5 GHz, and 4G at 2-8 GHz, placing it well within the microwave category.35, 35, 37

This frequency is miles away from the natural resonance of 7.83 Hz that our bodies are accustomed to, and far, far above current EMF levels (which are already damaging enough). At 60 GHz, the frequencies may impair oxygenation – as well as the body’s ability to produce vitamin D and melatonin.38

In this context, 5G and its 60 GHz delivery system are an assault on our bioregulatory systems.

NASA Research on Pulsating Magnetic Fields

NASA has had great interest in the Schumann resonances following the first space missions with astronauts. While several experiments were conducted on weightlessness,39 others were conducted on electromagnetic fields and their effect on cell cultures. Their EMF research and studies were outlined in a technical paper presented by Thomas J. Goodwin, Ph.D. of the Lyndon B. Johnson Space Center entitled Physiological and Molecular Genetic Effects of Time-Varying Electromagnetic Fields on Human Neuron Cells. Dr. Goodwin noted that: “We found the low-amplitude, rapidly time-varying magnetic fields exerted a very potent effect on the proliferation, morphology, and gene expression of the cells in culture”.40 Essentially, the studies’ findings indicated that cells grow faster and stronger and live longer when exposed to low-frequency pulsed electromagnetic fields like the Schumann resonances.

NASA developed and used a pulsed electromagnetic field generator to conduct their cell culture experiments. The generator was developed and used to generate the waveform in a strength of 1-6 mA (AC) square wave, 10 Hz variable duty cycle, which was pulse-width modulated. They patented this generator (US Patent, 6,485,963, B1 and MSC 22633-2 Notice to Issue). Cultured cells were subjected to this 10 Hz frequency and extremely low-level magnetic fields (-10 – 200m Gauss), which are far less than the field strength of the Earth.

One of the primary purposes of these studies was to develop a pulsed electromagnetic field device for use as a noninvasive countermeasure to enhance bone retention, prevent or alleviate muscle atrophy, and augment natural healing/regeneration processes for astronauts exposed to long durations in space. This research was a significant contribution toward enabling humans to live and work safely in space and is especially relevant to projected human space exploration. On Earth, this device could be useful in the treatment of various muscle diseases, age- and cancer-related muscle atrophy, osteoporosis, and other bone diseases.

Taken from this research, other manufacturers have now designed similar generators that produce pulsed ELFs (7.83 Hz) magnetic fields. These are being used by individuals to promote health and counterbalance potentially detrimental electrosmog.

Omnia metire quaecumque licet et immensaad mensuram tempestive redige

“Measure what is measurable and render measurable in time what as yet is not.”

~ Halberg Chronobiology Center, University of Minnesota

Becoming Coherent with the Schumann Resonance

Fortunately, there are a few things that can be done to improve a coherent relationship with the Schumann resonance. Incorporating these things into your life may help you gain the benefit of the positive effects of being in harmony with the Earth’s ionospheric heartbeat.

•. Spend time in nature, such as the forest or a beach. The simple act of enjoying and being in nature acts like a tuning fork entraining your vibration into coherence. Any nature spot will do – walk in bare feet on the Earth, take a nap on the grass, breathe fresh air.

•. Gaze at the stars as often as possible.

•. Listen to music that incorporates a Schumann frequency in the background during work or play. There are numerous commercial music CDs that incorporate the Schumann frequency as well as YouTube videos that are pleasant to watch.

•. Invest in a Schumann Resonator – Some researchers believe that by producing a 7.83 Hz signal with a field generator (Schumann device), we can reduce the irritating effects of man-made electromagnetic fields. By replicating the Earth’s natural rhythm, we may be providing ourselves (at least in our immediate vicinity) with a healthier environment. There are several devices that emit a 7.83 Hz frequency on the market available for purchase. I cannot recommend a particular device, but encourage anyone interested in a Schumann frequency generator to research any unit thoroughly before purchasing.

•. Continually educate yourself about the wireless industry and man-made electromagnetic fields.

Winfried Schumann Biography

Winfried Otto Schumann was born May 20, 1888, in Tübingen, Germany, the son of a physical chemist. His early years were spent in Kassel and in Berndorf, a town near Vienna. He majored in electrical engineering at the Technical College in Karlsruhe. In 1912, he earned a doctorate with high-voltage technology as his thesis.

Prior to the First World War, he managed the high voltage laboratory at Brown, Boveri & Cie. During the 1920s, he was made a professor at the Technical University in Stuttgart, where he had previously been employed as a research assistant. He subsequently took a position as professor of physics at the University of Jena. In 1924, he was made professor and director of the Electrophysical Laboratory at the Technical University of Munich.

The Munich laboratory subsequently became the Electrophysical Institute, where Schumann continued working until retiring from active research in 1961 at the age of 73 (he continued teaching for another two years). Schumann was 86 years old when he died on September 22, 1974.


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For more information on chronobiology, visit the Halberg Chronobiology Center – University of Minnesota.

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Acid-Base Regulation Therapy

Febuary 7, 2020

Acid-Base Regulation Therapy

Acid-base regulation therapy is an essential component of any metabolic program in Bioregulatory Medicine. Acid-base homeostasis exerts a major influence on protein function, thereby critically affecting tissue and organ performance. Deviations of systemic acidity in either direction can have adverse consequences and, when severe, can be life-threatening. Free radicals and toxins lead to a loss of electrons, which leads to a loss of protons. Consequently, our tissues become more acidic with the deposit of acids into the extracellular matrix, while the bones and tissues lose calcium, magnesium, potassium and trace minerals to compensate for buffer loss. Through excess elimination of acids in the urine, protons are lost out of the body. To a certain extent, the body’s elimination system can get rid of most excess metabolic acids; nonetheless, there is a slow deposit of acids into the extracellular matrix and finally an acidification of the cell (intra-cellular) occurs. Once the acids have entered the cell and in order to maintain electrical balance, potassium and magnesium will be excreted and washed out with the urine. Finally, an overall body (tissue) acidification takes place. In an acidic environment, all metabolic and digestive processes are slowed, kidney function is diminished, and all enzyme activity is decreased. Since an acidic bioregulatory terrain creates the ideal condition for the development of numerous chronic diseases, including cancer, it is important to develop therapeutic strategies to improve acid-base homeostasis.

The field of cellular biology has greatly advanced in the last two decades, and molecular biologists now understand that we live and die at the cellular level. All the processes, syndromes, and manifestations that are designated as diseases are, in part, a manifestation of the cell’s regulatory mechanism in creating energy, while combating, neutralizing, and excreting environmental toxins and metabolic waste.

Acid-Base Balance and its Relationship to Cellular Voltage

Cells function normally between a pH of 7.35 to 7.45. The acronym pH is the abbreviation of pondus hydrogenii and means the weight of hydrogen. PH is not only a measurement of hydrogen ion concentration, but also reflects the voltage of a solution. Pure water has a pH very close to 7 at 25 °C. Solutions with a pH less than 7 are said to be acidic and solutions with a pH greater than 7 are basic or alkaline.

Electrons are the negatively charged particles of an atom. Together, all the electrons of an atom create a negative charge that balances the positive charge of the protons in the atomic nucleus. If a solution is an electron donor, then this is designated with a minus sign (-) in front of the measured voltage. If the solution is an electron acceptor or “stealer”, then this is designated with a plus sign (+) in front of the measured voltage. Cellular voltage is measured in millivolts (mV) and can be converted to the pH scale which ranges from 0 to 14. A pH of 0 is the same as a voltage of +414 mV and a pH of 14 is the same as a voltage of -414 mV. Hence, a pH of 7 is considered neutral, and is neither an electron donor nor an electron acceptor, since its voltage is 0 mV. A pH of 7.35 is the same as voltage of -20 mV and a pH of 7.45 is the same as -25 mV. Normal cells exist between a voltage of -20 mV and -25 mV, and, therefore, are electron donors. Cancerous cells thrive in an acidic extracellular environment. Cellular mutations and damage occurs when cellular voltage is below the normal range of -20 mV and -25 mV. Hence, a cancerous terrain occurs when cellular membrane voltage is low, and the cells become electron “stealers”.

The lower the membrane voltage goes, the lower the cell pH becomes, and this lowers the oxygen available to the cell. All these lowered levels are associated with tumor formation and degenerative disease. As cellular voltage continues to drop, cells change from electron donors to electron acceptors or stealers – this is known as an electron polarity shift. When cellular voltage drops to +30 mV, then cancerous cells may form. When the cell voltage drops to this critical level that fosters cancer, only a few substances can pass in or out of the cell, such as water and glucose and the minerals potassium, cesium and rubidium. Oxygen cannot enter a low-voltage cancer cell – even if there is an abundance of oxygen in the blood. Cesium chloride, because of its electrical properties, can still enter the cancerous cell. When it does so, because of its extreme alkalinity, the cancer cell dies. Healthy cells are not affected by cesium because their cell voltage allows them to balance themselves. This is the principal behind cesium therapy (and a topic for another day).

Healthy cells regenerate at a cellular voltage of -50 mV. To achieve this voltage, an abundance of electron donors must be present around the cell. Important electron donors in the body, or reducing agents, include the electrolyte minerals potassium and magnesium. In addition, raw materials to make new healthy cells must be available. One of the most important raw materials for cells is water. The amount of oxygen that dissolves in water is dependent upon the voltage of the water. As voltage is increased, more oxygen will be dissolved in water. Conversely, as voltage drops, oxygen is released from solution. Our cells are 70% water, and as voltage drops, oxygen is lost. Cancer thrives in an oxygen-depleted, dehydrated environment.

pH Regulation and Body Buffers

The cells of the body can only live within a certain narrow pH range, or they will die. The pH scale ranges from 0 to 14, with numbers below 7 representing an acidic condition and above 7 representing an alkaline condition. Slight changes in pH value can cause marked alterations in the rates of chemical reactions in the cells, some being depressed, and others accelerated. For this reason, the regulation of pH is one of the most important aspects of homeostasis. PH is tightly controlled by buffering systems both inside the cells and outside the cells in the extracellular matrix. Thus, intracellular and extracellular buffers are the most immediate mechanism of defense against changes in systemic pH. Bone and proteins constitute a substantial proportion of these buffers. Additionally, organs such as the kidneys, lungs and liver play an important role in eliminating metabolic acids. The pH of the cells, although slightly lower than in the extracellular fluid, nevertheless changes approximately in proportion to extracellular fluid pH changes. Hence, if there are more acid waste deposits in the extracellular matrix, the cells become impregnated with acids and this can cause destructive intercellular processes to occur. Important extracellular buffers include bicarbonate and ammonia. The bicarbonate buffering system is especially important, as carbon dioxide can be shifted through carbonic acid to form hydrogen ions and bicarbonate (through a zinc-dependent enzyme process). Potassium, magnesium and phosphate act as intracellular buffers. The phosphate buffer system also plays a major role in buffering renal tubular fluid. If the system becomes depleted in potassium and magnesium, the body will use calcium from the skeletal tissues to act as a secondary buffer – leading to loss of bone density. In the red blood cells, hemoglobin is an important buffer.

Typical high-animal protein Western diets and endogenous metabolism produce acid, typically on the order of 1 mEq/kg body wt per day or approximately 70 mEq/d for a 70-kg person. Phosphoric acid and sulfuric acid are significant products of this normal metabolism of dietary nutrients, such as proteins and phospholipids. To maintain acid-base homeostasis, these nonvolatile acids must be excreted by the kidney. The kidneys are responsible for excretion of the fixed acids and this is also a critical role even though the amount involved (70-100 mmols/day) is small. The main reason for this renal importance is because there is no other way to excrete these acids. The amounts involved are still very large when compared to the plasma [H+] of only 40 nanomoles/liter. Thus, the kidneys play an extremely important role in acid-base balance, namely the reabsorption of the filtered bicarbonate. Again, bicarbonate is the predominant extracellular buffer against the fixed acids and it important that its plasma concentration should be defended against renal loss.

In acid-base balance, the kidney is responsible for two major activities:

  • Reabsorption of filtered bicarbonate: 4,000 to 5,000 mmol/day

  • Excretion of the fixed acids (acid anion and associated H+): about 1 mmol/kg/day

Both these processes involve secretion of H+ into the lumen by the renal tubule cells but only the second leads to excretion of H+ (protons) from the body. Anything consumed will affect our body’s pH values. When we take in something acidic or of low pH (low oxygen) values, the body either must pull alkaline minerals from within it to neutralize the acid or store the acid somewhere in the tissue. If consuming an acidic soda at pH 2.5, it takes 32 glasses of water at pH 10 to neutralize the acid. As the pH drops, the cells’ oxygen levels also drop, and their ability to function properly diminishes drastically.

Free Radical Pathology and Cellular Energy

A free radical can be defined as any molecular species capable of independent existence that contains an unpaired electron in an atomic orbital. The presence of an unpaired electron results in certain common properties that are shared by most radicals. Many radicals are unstable and highly reactive. Technically, they can either donate an electron to – or accept an electron from – other molecules, therefore behaving as oxidants or reductants. However, the free radical molecules that are missing electrons can damage cells by accepting electrons. In “stealing” electrons, these free radicals lower the voltage of cellular membranes. Free radicals can also deplete cellular energy by interfering with mitochondrial function and contribute to shortened lifespan. Cellular energy generation in the mitochondria is both a key source and key target of oxidative stress in the cells.

Damage occurs when the free radical encounters another molecule and seeks to find another electron to pair with its unpaired electron. The free radical often pulls an electron off a neighboring molecule, causing the affected molecule to become a free radical itself. The new free radical can then pull an electron off the next molecule, and a chemical chain reaction of radical production occurs. Such an event causes damage to the molecule, and thus to the cell that contains it, since the molecule often becomes dysfunctional. Cancer and degenerative diseases coexist with many types of free radicals, especially oxidative free radicals. The most important oxygen-containing free radicals in many disease states are hydroxyl radicals, superoxide anion radicals, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radicals, and peroxynitrite radicals. These are highly reactive species, capable in the nucleus, and in the membranes of cells, of damaging biologically relevant molecules such as DNA, proteins, carbohydrates, and lipids, which is associated with changes in their structure and functions.

Free radicals and other reactive oxygen species rob cells of electrons. They are derived from either byproducts of metabolism, essential metabolic processes in the human body, or from external sources, such as radiation, cigarette smoking, air pollutants, fluoridated or chlorinated water, industrial chemicals, etc. Free radical formation occurs continuously in the cells because of both enzymatic and non-enzymatic reactions. Enzymatic reactions include those involved in the respiratory chain, in phagocytosis, in prostaglandin synthesis, and in the cytochrome P-450 system (to name a few). Free radicals can also be formed in non-enzymatic reactions of oxygen with organic compounds as well as those initiated by ionizing reactions.

Antioxidants are molecules that donate electrons to cells and are very therapeutic for neutralizing free radicals in a cancerous terrain. Hence, one of the primary ways antioxidants protect against free radicals is by donating an electron to the free radical, so it no longer acts as a hungry scavenger stealing electrons from our tissues. Many minerals are also capable of donating electrons as well. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition. Synthetic antioxidants are recently reported to be dangerous to human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants.

Acid-base homeostasis is critical for normal physiology and health. Hence, multiple, often redundant pathways and processes exist to control systemic pH. Derangements in acid-base homeostasis, however, are common in clinical medicine and can often be related to the systems involved in acid-base transport in the kidneys. Nowadays it is beyond dispute that most of civilization’s diseases are conditioned by our poor nutritional habits. It is well established that diet and certain food components have a clear impact on acid-base balance. Several factors are involved with acid-base regulation, particularly the chemical composition of foods (i.e., their content of protein, and minerals such as chloride, phosphorus, sodium, potassium, calcium, and magnesium), the different intestinal absorption rates of the relevant nutrients, and importantly, the integrity of the intestinal microbiome. The gut microbial community includes approximately 1014 bacteria that normally reside in the gastrointestinal tract, reaching a microbial cell number that greatly exceeds the number of human cells of the body. These organisms play an important part in maintaining acid-base homeostasis.

Today’s civilization manifests diseases which are associated with extracellular matrix acidosis and loss of cellular voltage. These are sure criteria for metabolic derailment, with the danger of acute or chronic disease. By changing one’s nutrition to more mineral rich organic foods, getting adequate hydration, supplementing alkaline minerals and antioxidants into the diet, and deep breathing, pH balance and cellular voltage may be better restored.


Adrogue HJ, Madias NE: Tools for clinical assessment. In: Acid-Base Disorders and Their Treatment, edited by Gennari FJ, Adrogue HJ, Galla JH, Madias NE, editors, Boca Baton, FL, Taylor and Francis Group, 2005, pp 801–816.

Barnett, Y. A., & King, C. M. (1995). Investigation of antioxidant status. DNA-repair capacity and mutation as a function of age in humans. Mut. Res., 338, 115–128.

Bergendi, L., Benes, L., Durackova, Z., & Ferencik, M. (1999). Chemistry, physiology and pathology of free radicals. Life Sci., 65, 1865–1874.

Cadenas, E. (1997). Basic mechanisms of antioxidant activity. Biofactors, 6, 391–397

Goraya N, Wesson DE: Dietary interventions to improve outcomes in chronic kidney disease. Curr Opin Nephrol Hypertens 24: 505–510, 2015 [PubMed]

Hamm LL, Simon EE: Roles and mechanisms of urinary buffer excretion. Am J Physiol 253: F595–F605, 1987 [PubMed]

Hood VL, Tannen RL: Protection of acid-base balance by pH regulation of acid production. N Engl J Med 339: 819–826, 1998 [PubMed]

Lemann J, Jr., Bushinsky DA, Hamm LL: Bone buffering of acid and base in humans. Am J Physiol Renal Physiol 285: F811–F832, 2003 [PubMed]

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Ruffin VA, Salameh AI, Boron WF, Parker MD: Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol 5: 43, 2014 [PMC free article] [PubMed

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Thomson WST, Adams JF, Cowan RA. Clinical Acid-Base Balance. New York: Oxford University Press, 1997.

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GcMAF Immunotherapy

GcMAF Immunotherapy

Febuary 7, 2020

GcMAF Immunotherapy

More than 25 years ago, the immunologist and researcher Dr. Nobuto Yamamoto isolated and produced GcMAF (Globulin Component Macrophage Activating Factor) as an immunotherapy. Since then, studies have demonstrated that GcMAF enhances the ability of the immune system to fight pathogens and cancer cells, by enhancing macrophages and reducing alpha-NaGalase.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 Accordingly, its administration has potential benefits in patients with a variety of conditions, ranging from cancer (e.g., metastatic breast, metastatic colorectal, and prostate) to HIV.13, 14, 15 Dr. Yamamoto has authored or co-authored over 50 papers on immunology. In 2014, however, three of his articles were retracted16, 17, 18, giving rise to considerable negative media around GcMAF immunotherapy. Undaunted by the retractions, Dr. Yamamoto and colleagues have continued their research, further demonstrating that GcMAF has wide application for use in many diseases by activating macrophages and stimulating the immune system. Dr. Yamamoto patented the process of preparing GcMAF by treating glycosylated human group-specific component, also known as human vitamin D-binding protein, with glycosidases in 1990 and 2015.19, 20 The manufacturing process of GcMAF is very technical. GcMAF can be made via recombinant DNA technology, by inserting a small section of DNA into the bacterium E. coli. This piece of DNA reprograms the bacterium to make GcMAF. An impurity can be introduced at any step in this multistage protein manufacturing process. Hence, there is certainly risk of product contamination. Reputable manufacturers test the final product for purity and efficacy. At the research clinic Saisei Mirai in Japan, GcMAF is tested for macrophage phagocytic activity using mouse macrophages and sheep red blood cells at the University of Tokushima, Japan. The red blood cells are opsonized, which marks them for ingestion and destruction by activated macrophages. Under the microscope this can be seen as purple areas in the clear cells. They then calculate the Phagocytosis (ingestion) Index (PI). GcMAF Methods and Timing of Administration Route of administration GcMAF is administered by subcutaneous (SC) or intramuscular (IM) injection, using a Size 26G x 1/2″ (0.45 x 13 mm) or Size 27G needle with a 2.5 ml or 1 ml syringe (single use, sterile disposable). Moreover, some doctors may administer it by intravenous infusion (drip) or by IV “push” and intratumoral (IT) injection. Another option is using a nebulizer to deliver the protein to activate macrophages in the bronchus-associated lymphoid tissue (BALT) of the lungs. Oral administration of the protein is not effective because the GcMAF protein would be destroyed by stomach hydrochloric acid and pancreatic protease enzymes. Frequency and dosage In his early published human studies, Dr. Yamamoto always used the same dose: 100 nanograms (ng) per week in a single injection. 100 nanograms (100 billionths of a gram) is an extremely small amount. Dr. Yamamoto determined that the half-life of the activation effect in an activated macrophage is approximately 6 days. Therefore, he chose a once per week interval between GcMAF doses. Saisei Mirai in Japan, however, now produces a second generation high-dose GcMAF. Their doctors inject this product IM at 0.5 ml of “high dose GcMAF” (1500 ng/0.5 ml) 2-3 times per week in an integrative approach to treating cancer. They further recommend that more frequent dosing (daily or every second day) may be safely used with more advanced stage of disease, or initially in the treatment course. In certain cases, GcMAF is administered by intravenous (IV) injection, 0.5-1.0 ml 2-3 times per week in 20 ml or more saline. Saisei Mirai doctors also use IV GcMAF in addition to the usual IM/SC injections every week on alternate days. Duration of treatment The duration of GcMAF therapy depends on the individual’s condition. Usually, with most breast cancer patients 4 to 6 months is necessary to fully activate the immunity. Maintenance is often continued with oral colostrum MAF. Monitoring GcMAF Treatment GcMAF administration must always be monitored by a physician trained in its use. Aside from the usual breast cancer tests (monitoring the effectiveness of treatments), there are two additional tests that are used. The first is the monocyte count of a white blood cell differential. Monocytes produced in the bone marrow enter the blood, then migrate to organs and tissues where they mature into macrophages. Official nomenclature further subdivides monocytes into three subsets (a topic for another day). Low monocyte count, low phagocytic activity of monocytes, low lymphocyte count, low NK cell activity, and depressed TNF-α are often observed following standard external beam chest radiation therapy or cytotoxic chemotherapy for breast cancer. This has consequences for anticancer immune competence in the weeks and months following completion of standard treatment and is why immunotherapy is so important. GcMAF therapy increases the number of monocytes as it activates macrophages. A patient’s monocyte count will generally rise in the early stages of GcMAF treatment and indicates a response to GcMAF. Normal monocyte levels are between 2% and 10% of the total differential. Upward of 6% or more is considered optimum response to GcMAF treatment. Cancers and viruses both make alpha-NaGalase. Specialized laboratories can now measure the level of nagalase in the blood. An elevated nagalase test result reveals that either cancer or a virus (or both) could be present. It has been established that nagalase activity is directly proportional to viable tumor burden; whereas decreased nagalase activity is associated with improved clinical conditions. Hence, some doctors using GcMAF treatment employ nagalase testing to determine the efficacy of the therapy. Be advised that reference ranges differ slightly depending on the laboratory. Because the measurement of this enzyme can diagnose the presence of cancerous lesions below levels detectable by other diagnostic means, nagalase testing may become a standard biomarker for early cancer detection. GcMAF Side Effects There have been no reported side effects (nor toxic reactions) from GcMAF therapy. The primary reason being that its molecular structure is bioidentical (identical to the GcMAF made by the body). So, as long as the GcMAF is pure*, there is no reason to expect any side effects. *A pure GcMAF protein contains only molecules of a single protein, and no other molecules of any kind. Impurities cause compromised effectiveness, adverse reactions, and symptoms of toxicity. Beware because there are “bootleg” or phony versions of GcMAF being manufactured that are impure, contaminated, and consequently potentially toxic. These products are often sold over the internet, and their packaging may look identical to the real product. It is best to purchase GcMAF directly from the clinics in Japan21 or Europe. These clinics usually require the patient to undergo GcMAF treatment at the clinic, and then dismiss the patient with enough product to follow up at home for several weeks. Thousands of patients over the last two decades have been treated with GcMAF in the United Kingdom, Europe and Asia (especially Japan). But many of its practitioners have faced adversity. A UK factory where GcMAF was being manufactured was closed under claims that the product “might be contaminated.” Importation of GcMAF into the UK has been halted. Big Pharma was quick to realize that GcMAF was being manufactured and sold at a fraction of the cost of other immunotherapy products. Moreover, a universal cancer cure would destroy the profitability of the highly lucrative cancer industry, and collapse the American Cancer Society, hospitals, oncology clinics and pharmaceutical companies that depend on chemotherapy revenues to stay profitable. Consequently, shipments of GcMAF into the U.S. have been confiscated, and its use has been made illegal. Astoundingly, a few U.S. doctors who had been using GcMAF, or advocating its use, were found dead under suspicious circumstances; conspiracy rumors still abound. It is estimated that at least 350 doctors in 80 countries are using GcMAF, but currently research studies are limited to Japan and parts of Europe (e.g., Germany). Big Pharma and its regulatory agencies have done much to discredit – and make unavailable – the product. The internet is full of quackery websites discrediting GcMAF and the doctors who advocate its use. It is tragic that cytotoxic chemotherapy, which has very little proven efficacy in survival time, and which produces serious (and even fatal) side effects, can be marketed to the sick and dying – but a harmless body protein, studied for over twenty-five years as a promising immunotherapy agent, is not even available for research in the U.S. For more information, click here to visit our video library. 1. Dr. Nobuto Yamamoto was born in Japan April 25, 1925. He spent his adult life researching microbiology. In 1980, Dr. Yamamoto was appointed Professor of Microbiology and Immunology at Hahnemann University School of Medicine, where he continued his research in viral evolution. His immunological studies focused on the mechanism of macrophage activation and GcMAF. When Dr. Yamamoto retired from Hahnemann University in 1990, he returned to Temple University Medical School as a Research Professor of Biochemistry and studied the tumoricidal capacity of macrophages activated by GcMAF and cancer therapy with GcMAF. In 1994, Dr. Yamamoto founded the Socrates Institute for Therapeutic Immunology, where he continues to study the therapeutic efficacy of GcMAF for a variety of cancers and HIV. 2. Yamamoto N, and Kumashiro R, Conversion of vitamin D3 binding protein (group specific component) to a macrophage activating factor by the stepwise action of ß-galactosidase of B cells and sialidase of T cells, J. lmmunol. 151 2794–2802 (1993). 3. Yamamoto N, Homma S, Haddad JG, Kowalski MA, Vitamin D3 binding protein required for in vitro activation of macrophages after alkylglycerol treatment of mouse peritoneal cells, Immunology. 74 420–424 (1991). 4. Yamamoto N, and Homma S, Vitamin D3 binding protein (group specific component) is a precursor for the macrophage-activating signal, Proc.Natl. Acad. Sci. USA 88 8539–8543 (1991). 

5. Korbelik M, Naraparaju VR, Yamamoto N. The value of serum alpha-N-acetylgalactosaminidase measurement for the assessment of tumour response to radio- and photodynamic therapy.Br J Cancer. 1998 Mar; 77(6):1009-14.

6. Naraparaju VR, Yamamoto N. 1994. Roles of b-galactosidase of B lymphocytes and sialidase of T lymphocytes in inflammation primed activation of macrophages. Immunol Lett 43:143–148. 7. Yamamoto, N., and Homma, S. Vitamin D3 binding protein (group-specific component, Gc) is a precursor for the macrophage activating signal factor from lysophosphatidylcholine-treated lymphocytes.Proc. NatI. Acad. Sci. USA, 88: 8539-8543, 1991. 8. Yamamoto N, Ueda M, Benson CE. 2007. Treatment of HIV-infected patients with Gc protein-derived macrophage activating factor (GcMAF) eradicates HIV-infection. Proc 13th Int Cong Immunol. Italy: Medimond, Bologna. pp. 35–38. 9. Yamamoto N, Kumashiro R.. Conversion of vitamin D3 binding protein (Group specific component) to a macrophage activating factor by the stepwise action of b-galactosidase of B cells and sialidase of T cells. J Immunol 151:2794–2802, 1993. 10. Yamamoto N, Homma S, Millman I. 1991. Identification of the serum factor required for in vitro activation of macrophages: Role of vitamin D3 binding protein (Group specific component, Gc) in lysophospholipid activation of mouse peritoneal macrophages. J Immunol 147:273–280. 11. Nobuto Yamamoto, Masahiro Urade, Yoshihiko Koga, Nobuyuki Yamamoto, Theodor Sery and Masumi Ueda. Macrophages Activated By GCMAF Develop Enormous Variation of Receptors That Recognize and Eradicate Adenocarcinomas. Clinical Immunology, Volume 119, Supplement 1, 2006, Page S96. FOCIS 2006 Abstract Supplement – 6th Annual Meeting. 12. Yamamoto, Masahiro Urade, Yoshihiko Koga, Nobuyuki Yamamoto, Theodor Sery and Masumi Ueda. Macrophages Activated By GCMAF Develop Enormous Variation of Receptors That Recognize and Eradicate Adenocarcinomas. Nobuto 2006. 13. Thyer L. et al. GC protein-derived macrophage-activating factor decreases α-N-acetylgalactosaminidase levels in advanced cancer patients. Oncoimmunology. 2013;2(8): e25769. 14. Yamamoto N, Suyama H and Yamamoto N: Immunotherapy for prostate cancer with Gc protein-derived macrophage-activating factor, GcMAF. Transl Oncol 1: 65-72, 2008. 15. Gregory KJ, Zhao B, Bielenberg DR, Dridi S, Wu J, Jiang W, et al. (2010) Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells. PLoS ONE 5(10): e13428. doi:10.1371/journal.pone.0013428 16. Yamamoto N, Suyama H, Yamamoto N and Ushijima N: Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF). Int J Cancer 122: 461-467, 2008. Retraction: Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (GcMAF)’ [Int J Cancer. 2014] 17. Yamamoto N, Ushijima N and Koga Y: Immunotherapy of HIV infected patients with Gc protein-derived macrophage activating factor (GcMAF). J Med Virol 81: 16-21, 2009. – Retraction. Immunotherapy of HIV-infected patients with Gc protein-derived macrophage activating factor. [J Med Virol. 2014]

18. Yamamoto N, Suyama H, Nakazato H, Yamamoto N and Koga Y: Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage activating factor, GcMAF. Cancer Immunol Immunother 57: 1007-1016, 2008. – Retraction: Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, GcMAF. [Cancer Immunol Immunother. 2014] 19. – In vitro enzymatic conversion of glycosylated human vitamin D binding protein to a potent macrophage activating factor: Abstract: A novel, potent macrophage activating factor is prepared in vitro by treating glycosylated human group-specific component, also known as human vitamin D-binding protein, with glycosidases. Group-specific component, which is isolated from retired blood by known procedures, is thus readily converted to a highly potent macrophage activating factor. 20. 21. Saisei Mirai is a medical organization in Osaka, Japan, with the purpose of treating patients and developing and producing therapies, in particular immunotherapies such as GcMAF and colostrum MAF.

#GcMAF #Immunotherapy

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